Rotterdam Kidney Lab

Over Rotterdam Kidney Lab

Our research focuses on fluid and electrolyte handling by the kidney and its implications for common conditions such as hypertension and chronic kidney disease (CKD). To do so, we apply a translational approach that combines experimental work with clinical and epidemiological studies.

In the lab we focus on epithelial transport proteins, especially the sodium-chloride cotransporter (NCC). We use complementary techniques including cell and animal models, organoids, and ex vivo approaches (isolated perfused kidney, urinary extracellular vesicles). Recent contributions include the characterization of NCC regulation by potassium, angiotensin II, WNK-SPAK kinases, and calcineurin inhibitors.

In clinical studies we address the impact of the renal tubular mechanisms identified in the lab. Examples include the thiazide sensitivity of calcineurin inhibitor-induced hypertension, the renal tubular basis for salt-sensitivity in CKD, and the role of potassium in CKD (ongoing national trial with potassium supplementation). To analyze renal tubular transport non-invasively, we have developed novel methods to isolate, quantify, and characterize urinary extracellular vesicles.

Through our tertiary referral center we also focus on inherited kidney disease including polycystic kidney disease and tubulopathies with discovery of novel mutations in SCCN1A and KCNJ16.

Finally, we collaborate with the population-based Rotterdam Study in which serum and urinary electrolyte data are coupled to a range of phenotypic and genotypic data and outcomes.

Trefwoorden

• Adpkd
• Biomarkers
• Hypertension
• Internal Medicine
• Nephrology

Adres

• Hoofdkantoor

  Wytemaweg3015CN RotterdamZuid-Holland, Nederland

Team per functiegebied

Gebaseerd op 2 openbare functieprofielen, stand van 4 september 2026.

• Research / R&D2